Functional annotation for the Mootha dataset FOREL analysis
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چکیده
217414_x_at HBA2 3040 hemoglobin, alpha 2 hemoglobin complex [SUMMARY:] The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes the following five loci: 5'zeta pseudozeta pseudoalpha-1 alpha-2 alpha-1 -3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1 respectively; some nondeletion alpha thalassemias have also been reported. 12458 900.3 12490.49 3.79 217232_x_at 21626.6 1732.6 21695.89 3.64 211074_at 3015.92 245.3 3025.88 3.62
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